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Original title:
Functional role of Bcl10 and Malt1 in signal transduction from the FcεRI in mast cells and the LPA receptor in murine embryonic fibroblasts
Translated title:
Functional role of Bcl10 and Malt1 in signal transduction from the FcεRI in mast cells and the LPA receptor in murine embryonic fibroblasts
Author:
Klemm, Stefanie
Year:
2008
Document type:
Dissertation
Institution:
Fakultät Wissenschaftszentrum Weihenstephan
Advisor:
Ruland, Jürgen (Priv.-Doz. Dr.)
Referee:
Ruland, Jürgen (Priv.-Doz. Dr.); Duyster, Justus G. (Prof. Dr.); Wurst, Wolfgang (Prof. Dr.)
Language:
de
Subject group:
BIO Biowissenschaften
Keywords:
Bcl10, Malt1, NF-κB, FcεRI, G-Protein-gekoppelte Rezeptoren
Translated keywords:
Bcl10, Malt1, NF-κB, FcεRI, G-Protein-gekoppelte Rezeptoren
Controlled terms:
Mastzelle; Signaltransduktion
TUM classification:
BIO 220d
Abstract:
In dieser Arbeit wurden die in Lymphozyten essentiellen Adaptermoleküle B cell lymphoma 10 (Bcl10) und Mucosa-associated lymphoid tissue 1 (Malt1) als neue Schlüsselregulatoren der Signaltransduktion in Mastzellen als exemplarische myeloide Zelllinie identifiziert. Sie regulieren IgE-abhängige, anaphylaktische Langzeitreaktionen in vivo und sind für die FcεRI-induzierte Aktivierung des Transkriptionsfaktors Nuclear Factor κB (NF-κB) und die resultierende Produktion der Zytokine Tumornekrosefakto...    »
Translated abstract:
In this work, the essential lymphocyte adaptor molecules B cell lymphoma 10 (Bcl10) and mucosa-associated lymphoid tissue 1 (Malt1) have been identified as novel key regulators in signal transduction in mast cells as exemplary myeloid cell line. They regulate IgE-dependent anaphylactic late phase reactions in vivo and are responsible for the FcεRI-induced activation of the transcription factor nuclear Factor κB (NF-κB) and the resulting production of the cytokines tumor necrosis factor α and int...    »
WWW:
https://mediatum.ub.tum.de/?id=650255
Date of submission:
11.09.2007
Oral examination:
23.04.2008
Pages:
118
Urn (citeable URL):
https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20080429-650255-1-1
Last change:
08.06.2010
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