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Original title:
NT-proBNP als Prädiktor von major adverse cardiovascular events in der Kinderkardiologie
Translated title:
NT-proBNP as a predictor of major adverse cardiovascular events in children
Author:
Palm, Jonas Florian
Year:
2023
Document type:
Dissertation
Faculty/School:
TUM School of Medicine and Health
Advisor:
Ewert, Peter (Prof. Dr.)
Referee:
Ewert, Peter (Prof. Dr.); Hauser, Michael (Prof. Dr.); Stern, Heiko (Prof. Dr.)
Language:
de
Subject group:
MED Medizin
Keywords:
zlog, NT-proBNP, Komplikationen, MACE, Tod, Kinderkardiologie
Translated keywords:
zlog, NT-proBNP, adverse events, mortality, children, pediatric cardiology
TUM classification:
MED 410; MED 580
Abstract:
In dieser Promotionsarbeit wurde zunächst der zlog-Wert von NT-proBNP (abgekürzt zlog-NT-proBNP) als altersbereinigter Referenzwert eingeführt, um die stark altersabhängigen Referenzintervalle dieses Biomarkers zu standardisieren (analog zu einem normalen Z-Wert) . Anschließend wurde zlog-NT-proBNP in einer großen Kohorte (n=910) von Kindern mit angeborenen Herzfehlern aller Altersstufen hinsichtlich seiner prognostischen Aussagekraft zur Vorhersage von schwerwiegenden kardiovaskulären Ereigniss...     »
Translated abstract:
In this doctoral thesis, the zlog value of NT-proBNP (abbreviated zlog-NT-proBNP) was introduced as an age-adjusted reference to standardize the highly age-dependent reference intervals of this biomarker in a similar way as by means of a common z-score. Thereafter, the prognostic power of zlog-NT-proBNP for the occurrence of major adverse cardiovascular events throughout childhood in patients with congenital heart diseases was investigated.
WWW:
https://mediatum.ub.tum.de/?id=1661742
Date of submission:
27.06.2022
Oral examination:
29.09.2023
File size:
18422471 bytes
Pages:
76
Urn (citeable URL):
https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20230929-1661742-1-1
Last change:
31.10.2023
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