This study presents a tissue replacement material, bioactivated by incorporation of the photosynthetically active algae, Chlamydomonas reinhardtii. In a full-skin defect mouse model, the clinical and immunological tolerance to the material, and the creation of a chimeric tissue of algae and mouse cells is shown. In vivo and in vitro experiments demonstrate how the bioactivated material can produce oxygen. Photosynthetically active tissue replacement materials are introduced as method for local, vessel-independent tissue oxygenation and as a possible new treatment option.
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This study presents a tissue replacement material, bioactivated by incorporation of the photosynthetically active algae, Chlamydomonas reinhardtii. In a full-skin defect mouse model, the clinical and immunological tolerance to the material, and the creation of a chimeric tissue of algae and mouse cells is shown. In vivo and in vitro experiments demonstrate how the bioactivated material can produce oxygen. Photosynthetically active tissue replacement materials are introduced as method for local,...
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