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- Original title:
- The role of the SCFFbxo9 in the pathogenesis and therapy of Multiple Myeloma
- Translated title:
- The role of the SCFFbxo9 in the pathogenesis and therapy of Multiple Myeloma
- Author:
- Targosz, Bianca-Sabrina Yvonne
- Year:
- 2013
- Document type:
- Dissertation
- Faculty/School:
- Fakultät Wissenschaftszentrum Weihenstephan
- Advisor:
- Bassermann, Florian C. (Priv.-Doz. Dr.)
- Referee:
- Bassermann, Florian C. (Priv.-Doz. Dr.); Schwechheimer, Claus (Prof. Dr.)
- Language:
- de
- Subject group:
- MED Medizin
- Keywords:
- Multiples Myelom, Ubiquitin Proteasom System, Fbxo9, CK2
- Translated keywords:
- Multiple Myeloma, Ubiquitin Proteasom System, Fbxo9, CK2
- Abstract:
- Multiples Myelom wird effektiv durch Inhibition des Ubiquitin Proteasom Systems behandelt. Als zugrundeliegender, krankheitsspezifischer Mechanismus wird hier erstmalig die Deregulation der mTOR Signalwege über die Ubiquitin-Ligase Fbxo9 und die Kinase CK2 identifiziert, wobei Fbxo9-Expression in Myelomzellen mit Überleben und besserem Ansprechen auf Proteasominhibitoren korreliert. Somit werden Fbxo9 und CK2 als neue therapeutische Zielstrukturen sowie Biomarker im Multiplen Myelom charakterisi... »
- Translated abstract:
- Multiple Myeloma is effectively treated by inhibition of the ubiquitin proteasome system. The deregulation of mTOR signalling pathways via the ubiquitin ligase Fbxo9 and the kinase CK2 is here newly identified as the underlying, myeloma-specific mechanism, whereas Fbxo9 expression in myeloma cells correlated with survival and better response to proteasome inhibitors. As such, Fbxo9 and CK2 are characterised as novel therapeutic target structures as well as biomarker in Multiple Myeloma.
- WWW:
- https://mediatum.ub.tum.de/?id=1162505
- Date of submission:
- 30.01.2013
- Oral examination:
- 03.06.2013
- File size:
- 5554380 bytes
- Pages:
- 124
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20130603-1162505-0-0
- Last change:
- 25.06.2013
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