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Document type:
Zeitschriftenaufsatz
Author(s):
Schemann, Michael; Kugler, Eva Maria; Buhner, Sabine; Eastwood, Christopher; Donovan, Jemma; Jiang, Wen; Grundy, David
Title:
The mast cell degranulator compound 48/80 directly activates neurons.
Abstract:
BACKGROUND: Compound 48/80 is widely used in animal and tissue models as a "selective" mast cell activator. With this study we demonstrate that compound 48/80 also directly activates enteric neurons and visceral afferents. METHODOLOGY/PRINCIPAL FINDINGS: We used in vivo recordings from extrinsic intestinal afferents together with Ca(++) imaging from primary cultures of DRG and nodose neurons. Enteric neuronal activation was examined by Ca(++) and voltage sensitive dye imaging in isolated gut pre...     »
Keywords:
Animals, Guinea Pigs, Male, Neurons/*drug effects/metabolism, Calcium Signaling/drug effects, Enteric Nervous System/drug effects, Ganglia, Spinal/drug effects/metabolism, Nodose Ganglion/drug effects/metabolism, p-Methoxy-N-methylphenethylamine/administration & dosage/*pharmacology, Sensory Receptor Cells/drug effects/metabolism, Visceral Afferents/drug effects
Journal title:
PloS one
Year:
2012
Journal volume:
7
Journal issue:
12
Pages contribution:
e52104
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0052104
Print-ISSN:
1932-6203 1932-6203
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