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Title:

Neuronal {cGMP} kinase {I} is essential for stimulation of duodenal bicarbonate secretion by luminal acid.

Document type:
Zeitschriftenaufsatz
Author(s):
Singh, Anurag Kumar; Spiessberger, Beate; Zheng, Wen; Xiao, Fang; Lukowski, Robert; Wegener, Jorg W.; Weinmeister, Pascal; Saur, Dieter; Klein, Sabine; Schemann, Michael; Krueger, Dagmar; Seidler, Ursula; Hofmann, Franz
Abstract:
Brief contact of the duodenal mucosa with luminal acid elicits a long-lasting bicarbonate (HCO(3)(-)) secretory response, which is believed to be the primary protective mechanism against mucosal damage. Here, we show that cGMP-dependent protein kinase type I-knockout (cGKI(-/-)) mice are unable to respond to a physiological H(+) stimulus with a HCO(3)(-) secretory response and spontaneously develop duodenal ulcerations. Smooth muscle-selective cGKI knock-in rescued the motility disturbance but n...     »
Keywords:
Mice, Knockout, Animals, Mice, Acids/*metabolism, Bicarbonates/*metabolism, Colforsin/pharmacology, Cyclic GMP-Dependent Protein Kinase Type I, Cyclic GMP-Dependent Protein Kinases/genetics/*metabolism, Duodenal Ulcer/metabolism/pathology, Duodenum/anatomy & histology/*metabolism, Interstitial Cells of Cajal/cytology/metabolism, Intestinal Mucosa/cytology/drug effects/metabolism/pathology, Neurons/*enzymology, Solitary Nucleus/cytology/metabolism, Vagotomy, Vagus Nerve/metabolism
Journal title:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Year:
2012
Journal volume:
26
Month:
apr
Journal issue:
4
Pages contribution:
1745--1754
Language:
eng
Fulltext / DOI:
doi:10.1096/fj.11-200394
Print-ISSN:
1530-6860 0892-6638
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