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Author(s):
Lee, Dong-Kuk; Bhunia, Anirban; Kotler, Samuel A.; Ramamoorthy, Ayyalusamy 
Title:
Detergent-type membrane fragmentation by MSI-78, MSI-367, MSI-594, and MSI-843 antimicrobial peptides and inhibition by cholesterol: a solid-state nuclear magnetic resonance study 
Abstract:
Multidrug resistance against the existing antibiotics is becoming a global threat, and any potential drug that can be designed using cationic antimicrobial peptides (AMP) could be an alternate solution to alleviate this existing problem. The mechanism of action of killing bacteria by an AMP differs drastically in comparison to that of small molecule antibiotics. The main target of AMPs is to interact with the lipid bilayer of the cell membrane and disrupt it to kill bacteria. Consequently, the m...    »
 
Journal title:
Biochemistry 
Year:
2015 
Journal volume:
54 
Journal issue:
10 
Pages contribution:
1897--1907 
Print-ISSN:
1520-4995