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Document type:
Zeitschriftenaufsatz 
Author(s):
Brender, Jeffrey R.; Krishnamoorthy, Janarthanan; Sciacca, Michele F M; Vivekanandan, Subramanian; D'Urso, Luisa; Chen, Jennifer; {La Rosa}, Carmelo; Ramamoorthy, Ayyalusamy 
Title:
Probing the sources of the apparent irreproducibility of amyloid formation: drastic changes in kinetics and a switch in mechanism due to micellelike oligomer formation at critical concentrations of IAPP 
Abstract:
The aggregation of amyloidogenic proteins is infamous for being highly chaotic, with small variations in conditions sometimes leading to large changes in aggregation rates. Using the amyloidogenic protein IAPP (islet amyloid polypeptide protein, also known as amylin) as an example, we show that a part of this phenomenon may be related to the formation of micellelike oligomers at specific critical concentrations and temperatures. We show that pyrene fluorescence can sensitively detect micellelike...    »
 
Journal title:
The journal of physical chemistry. B 
Year:
2015 
Journal volume:
119 
Journal issue:
Pages contribution:
2886--2896 
Print-ISSN:
1520-5207