Kinases are involved in many diseases and represent an important class of drug targets. In this study, an optimized chemical proteomics approach (Kinobeads) was harnessed to elucidate the target space of over 1,200 kinase inhibitors (libraries of tool compounds and clinical drugs), in order to identify potential new chemical probes and novel compounds for the so far undruggable kinome as well as to better understand their modes of action. Indeed, several hundred new potential chemical probes were found for various kinases, many of which were missing a highly selective inhibitor.
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Kinases are involved in many diseases and represent an important class of drug targets. In this study, an optimized chemical proteomics approach (Kinobeads) was harnessed to elucidate the target space of over 1,200 kinase inhibitors (libraries of tool compounds and clinical drugs), in order to identify potential new chemical probes and novel compounds for the so far undruggable kinome as well as to better understand their modes of action. Indeed, several hundred new potential chemical probes wer...
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