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Document type:
Zeitschriftenaufsatz 
Author(s):
Jin, Kelly; Wilson, Kenneth A.; Beck, Jennifer N.; Nelson, Christopher S.; Brownridge, George W.; Harrison, Benjamin R.; Djukovic, Danijel; Raftery, Daniel; Brem, Rachel B.; Yu, Shiqing; Drton, Mathias; Shojaie, Ali; Kapahi, Pankaj; Promislow, Daniel 
Title:
Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila 
Abstract:
In most organisms, dietary restriction (DR) increases lifespan. However, several studies have found that genotypes within the same species vary widely in how they respond to DR. To explore the mechanisms underlying this variation, we exposed 178 inbred Drosophila melanogaster lines to a DR or ad libitum (AL) diet, and measured a panel of 105 metabolites under both diets. Twenty four out of 105 metabolites were associated with the magnitude of the lifespan response. These included proteinogenic a...    »
 
Dewey Decimal Classification:
510 Mathematik 
Journal title:
PLOS Genetics 
Year:
2020 
Journal volume:
16 
Year / month:
2020-07 
Quarter:
3. Quartal 
Month:
Jul 
Journal issue:
Pages contribution:
e1008835 
Language:
en 
Publisher:
Public Library of Science (PLoS) 
Print-ISSN:
1553-7390 
E-ISSN:
1553-7404 
Accepted:
06.05.2020 
Date of publication:
09.07.2020 
Semester:
SS 20 
TUM Institution:
Lehrstuhl für Mathematische Statistik 
Format:
Text