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Document type:
Zeitschriftenaufsatz 
Author(s):
Saez-Rodriguez, J.; Hammerle-Fickinger, A.; Dalal, O.; Klamt, S.; Gilles, E.D.; Conradi, C 
Title:
Multistability of signal transduction motifs 
Abstract:
Protein domains are the basic units of signalling processes. The mechanisms they are involved in usually follow recurring patterns, such as phosphorylation/dephosphorylation cycles. A set of common motifs was defined and their dynamic models were analysed with respect to number and stability of steady states. In a first step, Feinberg’s chemical reaction network theory was used to determine whether a motif can show multistationarity or not. The analysis revealed that, apart from double-step acti...    »
 
Journal title:
IET Systems Biolology 
Year:
2008 
Journal volume:
Journal issue:
(2) 
Pages contribution:
80-93 
Language:
en 
TUM Institution:
Zentralinstitut für Ernährungs- und Lebensmittelforschung / Abteilung Physiologie 
Format:
Text