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Document type:
Journal Article 
Author(s):
Blutke, Andreas; Sun, Na; Xu, Zhihao; Buck, Achim; Harrison, Luke; Schriever, Sonja C; Pfluger, Paul T; Wiles, David; Kunzke, Thomas; Huber, Katharina; Schlegel, Jürgen; Aichler, Michaela; Feuchtinger, Annette; Matiasek, Kaspar; Hauck, Stefanie M; Walch, Axel 
Title:
Light sheet fluorescence microscopy guided MALDI-imaging mass spectrometry of cleared tissue samples. 
Abstract:
Light sheet fluorescence microscopy (LSFM) of optically cleared biological samples represents a powerful tool to analyze the 3-dimensional morphology of tissues and organs. Multimodal combinations of LSFM with additional analyses of the identical sample help to limit the consumption of restricted specimen and reduce inter-sample variation. Here, we demonstrate the proof-of-concept that LSFM of cleared brain tissue samples can be combined with Matrix Assisted Laser Desorption/Ionization-Mass Spec...    »
 
Journal title abbreviation:
Sci Rep 
Year:
2020 
Journal volume:
10 
Journal issue:
Print-ISSN:
2045-2322 
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)