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Document type:
Journal Article 
Author(s):
Lundsgaard, Anne-Marie; Fritzen, Andreas M; Nicolaisen, Trine S; Carl, Christian S; Sjøberg, Kim A; Raun, Steffen H; Klein, Anders B; Sanchez-Quant, Eva; Langer, Jakob; Ørskov, Cathrine; Clemmensen, Christoffer; Tschöp, Matthias H; Richter, Erik A; Kiens, Bente; Kleinert, Maximilian 
Title:
Glucometabolic consequences of acute and prolonged inhibition of fatty acid oxidation. 
Abstract:
Excessive circulating FAs have been proposed to promote insulin resistance (IR) of glucose metabolism by increasing the oxidation of FAs over glucose. Therefore, inhibition of FA oxidation (FAOX) has been suggested to ameliorate IR. However, prolonged inhibition of FAOX would presumably cause lipid accumulation and thereby promote lipotoxicity. To understand the glycemic consequences of acute and prolonged FAOX inhibition, we treated mice with the carnitine palmitoyltransferase 1 (CPT-1) inhibit...    »
 
Journal title abbreviation:
J Lipid Res 
Year:
2020 
Journal volume:
61 
Journal issue:
Pages contribution:
10-19 
Fulltext / DOI:
Print-ISSN:
0022-2275 
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)