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Document type:
Journal Article 
Author(s):
Fischer, Katrin; Fenzl, Anna; Liu, Dianxin; Dyar, Kenneth A; Kleinert, Maximilian; Brielmeier, Markus; Clemmensen, Christoffer; Fedl, Anna; Finan, Brian; Gessner, Andre; Jastroch, Martin; Huang, Jianfeng; Keipert, Susanne; Klingenspor, Martin; Brüning, Jens C; Kneilling, Manfred; Maier, Florian C; Othman, Ahmed E; Pichler, Bernd J; Pramme-Steinwachs, Ines; Sachs, Stephan; Scheideler, Angelika; Thaiss, Wolfgang M; Uhlenhaut, Henriette; Ussar, Siegfried; Woods, Stephen C; Zorn, Julia; Stemmer, Ker...    »
 
Title:
The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation. 
Abstract:
During β-adrenergic stimulation of brown adipose tissue (BAT), p38 phosphorylates the activating transcription factor 2 (ATF2) which then translocates to the nucleus to activate the expression of Ucp1 and Pgc-1α. The mechanisms underlying ATF2 target activation are unknown. Here we demonstrate that p62 (Sqstm1) binds to ATF2 to orchestrate activation of the Ucp1 enhancer and Pgc-1α promoter. P62Δ69-251 mice show reduced expression of Ucp1 and Pgc-1α with impaired ATF2 genomic binding. Modulation...    »
 
Journal title abbreviation:
Nat Commun 
Year:
2020 
Journal volume:
11 
Journal issue:
Print-ISSN:
2041-1723 
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)