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Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Ziak, Jakub; Weissova, Romana; Jeřábková, Kateřina; Janikova, Martina; Maimon, Roy; Petrasek, Tomas; Pukajova, Barbora; Kleisnerova, Marie; Wang, Mengzhe; Brill, Monika S; Kasparek, Petr; Zhou, Xunlei; Alvarez-Bolado, Gonzalo; Sedlacek, Radislav; Misgeld, Thomas; Stuchlik, Ales; Perlson, Eran; Balastik, Martin 
Title:
CRMP2 mediates Sema3F-dependent axon pruning and dendritic spine remodeling. 
Abstract:
Regulation of axon guidance and pruning of inappropriate synapses by class 3 semaphorins are key to the development of neural circuits. Collapsin response mediator protein 2 (CRMP2) has been shown to regulate axon guidance by mediating semaphorin 3A (Sema3A) signaling; however, nothing is known about its role in synapse pruning. Here, using newly generated crmp2-/- mice we demonstrate that CRMP2 has a moderate effect on Sema3A-dependent axon guidance in vivo, and its deficiency leads to a mild...    »
 
Journal title abbreviation:
EMBO Rep 
Year:
2020 
Journal volume:
21 
Journal issue:
Fulltext / DOI:
Print-ISSN:
1469-221X 
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)