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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Snaidero, Nicolas; Schifferer, Martina; Mezydlo, Aleksandra; Zalc, Bernard; Kerschensteiner, Martin; Misgeld, Thomas 
Title:
Myelin replacement triggered by single-cell demyelination in mouse cortex. 
Abstract:
Myelin, rather than being a static insulator of axons, is emerging as an active participant in circuit plasticity. This requires precise regulation of oligodendrocyte numbers and myelination patterns. Here, by devising a laser ablation approach of single oligodendrocytes, followed by in vivo imaging and correlated ultrastructural reconstructions, we report that in mouse cortex demyelination as subtle as the loss of a single oligodendrocyte can trigger robust cell replacement and remyelination ti...    »
 
Journal title abbreviation:
Nat Commun 
Year:
2020 
Journal volume:
11 
Journal issue:
Print-ISSN:
2041-1723 
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)