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Document type:
Article; Journal Article 
Author(s):
Mufazalov, Ilgiz A; Andruszewski, David; Schelmbauer, Carsten; Heink, Sylvia; Blanfeld, Michaela; Masri, Joumana; Tang, Yilang; Schüler, Rebecca; Eich, Christina; Wunderlich, F Thomas; Karbach, Susanne H; Bluestone, Jeffrey A; Korn, Thomas; Waisman, Ari 
Title:
Cutting Edge: IL-6-Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression. 
Abstract:
IL-6 binds to the IL-6R α-chain (IL-6Rα) and signals via the signal transducer gp130. Recently, IL-6 was found to also bind to the cell surface glycoprotein CD5, which would then engage gp130 in the absence of IL-6Rα. However, the biological relevance of this alternative pathway is under debate. In this study, we developed a mouse model, in which murine IL-6 is overexpressed in a CD11c-Cre-dependent manner. Transgenic mice developed a lethal immune dysregulation syndrome with increased numbers o...    »
 
Journal title abbreviation:
J Immunol 
Year:
2020 
Journal volume:
204 
Journal issue:
Pages contribution:
747-751 
Fulltext / DOI:
Print-ISSN:
0022-1767 
TUM Institution:
Molekulare Immunologie (Prof. Knolle); Neurologische Klinik und Poliklinik