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Document type:
Journal Article 
Author(s):
Baumann, Tobias; Dunkel, Andreas; Schmid, Christian; Schmitt, Sabine; Hiltensperger, Michael; Lohr, Kerstin; Laketa, Vibor; Donakonda, Sainitin; Ahting, Uwe; Lorenz-Depiereux, Bettina; Heil, Jan E; Schredelseker, Johann; Simeoni, Luca; Fecher, Caroline; Körber, Nina; Bauer, Tanja; Hüser, Norbert; Hartmann, Daniel; Laschinger, Melanie; Eyerich, Kilian; Eyerich, Stefanie; Anton, Martina; Streeter, Matthew; Wang, Tina; Schraven, Burkhart; Spiegel, David; Assaad, Farhah; Misgeld, Thomas; Zischka, Ha...    »
 
Title:
Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal. 
Abstract:
Regulatory myeloid immune cells, such as myeloid-derived suppressor cells (MDSCs), populate inflamed or cancerous tissue and block immune cell effector functions. The lack of mechanistic insight into MDSC suppressive activity and a marker for their identification has hampered attempts to overcome T cell inhibition and unleash anti-cancer immunity. Here, we report that human MDSCs were characterized by strongly reduced metabolism and conferred this compromised metabolic state to CD8+ T cells, the...    »
 
Journal title abbreviation:
Nat Immunol 
Year:
2020 
Journal volume:
21 
Journal issue:
Pages contribution:
555-566 
Print-ISSN:
1529-2908 
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Experimentelle Onkologie und Therapieforschung; Institut für Humangenetik; Institut für Toxikologie und Umwelthygiene; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld); Molekulare Allergologie (Prof. Schmidt-Weber); Molekulare Immunologie (Prof. Knolle); Neurologische Klinik und Poliklinik; Professur für Experimentelle Dermato-Immunologie (Prof. Eyerich); Roman Herzog Comprehensive Cancer Center 
Occurrences: