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Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Kühne, Jenny Franziska; Neudörfl, Christine; Beushausen, Kerstin; Keil, Jana; Malysheva, Svitlana; Wandrer, Franziska; Haller, Hermann; Messerle, Martin; Blume, Cornelia; Neuenhahn, Michael; Schlott, Fabian; Hammerschmidt, Wolfgang; Zeidler, Reinhard; Falk, Christine S 
Title:
Differential effects of Belatacept on virus-specific memory versus de novo allo-specific T cell responses of kidney transplant recipients and healthy donors. 
Abstract:
Belatacept, Nulojix®, inhibits the interaction of CD28 on naïve T cells with B7.1/B7.2 (CD80/86) on antigen presenting cells, leading to T cell hyporesponsiveness and anergy and is approved as immunosuppressive drug in kidney transplantation. Due to its specificity for B7.1/2 molecules, side effects are reduced compared to other immunosuppressive drugs like calcineurin- and mTOR-inhibitors. Kidney transplant recipients under Belatacept-based immunosuppression presented with superior renal functi...    »
 
Journal title abbreviation:
Transpl Immunol 
Year:
2020 
Journal volume:
61 
Print-ISSN:
0966-3274 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene