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Document type:
Article; Journal Article 
Author(s):
Bajic, Danica; Niemann, Adrian; Hillmer, Anna-Katharina; Mejias-Luque, Raquel; Bluemel, Sena; Docampo, Melissa; Funk, Maja C; Tonin, Elena; Boutros, Michael; Schnabl, Bernd; Busch, Dirk H; Miki, Tsuyoshi; Schmid, Roland M; van den Brink, Marcel R M; Gerhard, Markus; Stein-Thoeringer, Christoph K 
Title:
Gut Microbiota-Derived Propionate Regulates the Expression of Reg3 Mucosal Lectins and Ameliorates Experimental Colitis in Mice. 
Abstract:
BACKGROUND AND AIMS: Regenerating islet-derived protein type 3 [Reg3] lectins are antimicrobial peptides at mucosal surfaces of the gut, whose expression is regulated by pathogenic gut microbes via interleukin-22- or Toll-like receptor signalling. In addition to antimicrobial effects, tissue protection is hypothesized, but has been poorly investigated in the gut. METHODS: We applied antibiotic-induced microbiota perturbations, gnotobiotic approaches and a dextran-sodium sulfate [DSS] colitis mod...    »
 
Journal title abbreviation:
J Crohns Colitis 
Year:
2020 
Journal volume:
14 
Journal issue:
10 
Pages contribution:
1462-1472 
Fulltext / DOI:
Print-ISSN:
1873-9946 
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene