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Document type:
Article; Journal Article 
Author(s):
Stenger, Dana; Stief, Tanja A; Kaeuferle, Theresa; Willier, Semjon; Rataj, Felicitas; Schober, Kilian; Vick, Binje; Lotfi, Ramin; Wagner, Beate; Grünewald, Thomas G P; Kobold, Sebastian; Busch, Dirk H; Jeremias, Irmela; Blaeschke, Franziska; Feuchtinger, Tobias 
Title:
Endogenous TCR promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR/Cas9-mediated TCR knockout CAR. 
Abstract:
Anti-CD19 chimeric antigen receptor (CAR) T cells showed significant antileukemic activity in B-precursor acute lymphoblastic leukemia (ALL). Allogeneic, HLA-mismatched off-the-shelf third-party donors may offer ideal fitness of the effector cells, but carry the risk of graft-versus-host disease. Knockout (KO) of the endogenous T-cell receptor (TCR) in CD19-CAR-T cells may be a promising solution. Here, we induced a CRISPR/Cas9-mediated KO of the TCRβ chain in combination with a second-generatio...    »
 
Journal title abbreviation:
Blood 
Year:
2020 
Journal volume:
136 
Journal issue:
12 
Pages contribution:
1407-1418 
Fulltext / DOI:
Print-ISSN:
0006-4971 
TUM Institution:
611; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene