User: Guest  Login
Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Jäger, Elisabeth; Murthy, Supriya; Schmidt, Caroline; Hahn, Magdalena; Strobel, Sarah; Peters, Anna; Stäubert, Claudia; Sungur, Pelin; Venus, Tom; Geisler, Mandy; Radusheva, Veselina; Raps, Stefanie; Rothe, Kathrin; Scholz, Roger; Jung, Sebastian; Wagner, Sylke; Pierer, Matthias; Seifert, Olga; Chang, Wenhan; Estrela-Lopis, Irina; Raulien, Nora; Krohn, Knut; Sträter, Norbert; Hoeppener, Stephanie; Schöneberg, Torsten; Rossol, Manuela; Wagner, Ulf 
Title:
Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis. 
Abstract:
Increased extracellular Ca2+ concentrations ([Ca2+]ex) trigger activation of the NLRP3 inflammasome in monocytes through calcium-sensing receptor (CaSR). To prevent extraosseous calcification in vivo, the serum protein fetuin-A stabilizes calcium and phosphate into 70-100 nm-sized colloidal calciprotein particles (CPPs). Here we show that monocytes engulf CPPs via macropinocytosis, and this process is strictly dependent on CaSR signaling triggered by increases in [Ca2+]ex. Enhanced macropinocyto...    »
 
Journal title abbreviation:
Nat Commun 
Year:
2020 
Journal volume:
11 
Journal issue:
Print-ISSN:
2041-1723 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene