User: Guest  Login
Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Kanoldt, Verena; Kluger, Carleen; Barz, Christiane; Schweizer, Anna-Lena; Ramanujam, Deepak; Windgasse, Lukas; Engelhardt, Stefan; Chrostek-Grashoff, Anna; Grashoff, Carsten 
Title:
Metavinculin modulates force transduction in cell adhesion sites. 
Abstract:
Vinculin is a ubiquitously expressed protein, crucial for the regulation of force transduction in cells. Muscle cells express a vinculin splice-isoform called metavinculin, which has been associated with cardiomyopathies. However, the molecular function of metavinculin has remained unclear and its role for heart muscle disorders undefined. Here, we have employed a set of piconewton-sensitive tension sensors to probe metavinculin mechanics in cells. Our experiments reveal that metavinculin bears...    »
 
Journal title abbreviation:
Nat Commun 
Year:
2020 
Journal volume:
11 
Journal issue:
Print-ISSN:
2041-1723 
TUM Institution:
Institut für Pharmakologie und Toxikologie