User: Guest  Login
Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Weinberger, Tobias; Esfandyari, Dena; Messerer, Denise; Percin, Gulce; Schleifer, Christian; Thaler, Raffael; Liu, Lulu; Stremmel, Christopher; Schneider, Vanessa; Vagnozzi, Ronald J; Schwanenkamp, Jennifer; Fischer, Maximilian; Busch, Katrin; Klapproth, Kay; Ishikawa-Ankerhold, Hellen; Klösges, Lukas; Titova, Anna; Molkentin, Jeffery D; Kobayashi, Yasuhiro; Engelhardt, Stefan; Massberg, Steffen; Waskow, Claudia; Perdiguero, Elisa Gomez; Schulz, Christian 
Title:
Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation. 
Abstract:
Arterial macrophages have different developmental origins, but the association of macrophage ontogeny with their phenotypes and functions in adulthood is still unclear. Here, we combine macrophage fate-mapping analysis with single-cell RNA sequencing to establish their cellular identity during homeostasis, and in response to angiotensin-II (AngII)-induced arterial inflammation. Yolk sac erythro-myeloid progenitors (EMP) contribute substantially to adventitial macrophages and give rise to a defin...    »
 
Journal title abbreviation:
Nat Commun 
Year:
2020 
Journal volume:
11 
Journal issue:
Print-ISSN:
2041-1723 
TUM Institution:
Institut für Pharmakologie und Toxikologie