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Document type:
Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. 
Author(s):
Trembinski, D Julia; Bink, Diewertje I; Theodorou, Kosta; Sommer, Janina; Fischer, Ariane; van Bergen, Anke; Kuo, Chao-Chung; Costa, Ivan G; Schürmann, Christoph; Leisegang, Matthias S; Brandes, Ralf P; Alekseeva, Tijna; Brill, Boris; Wietelmann, Astrid; Johnson, Christopher N; Spring-Connell, Alexander; Kaulich, Manuel; Werfel, Stanislas; Engelhardt, Stefan; Hirt, Marc N; Yorgan, Kaja; Eschenhagen, Thomas; Kirchhof, Luisa; Hofmann, Patrick; Jaé, Nicolas; Wittig, Ilka; Hamdani, Nazha; Bischof, C...    »
 
Title:
Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction. 
Abstract:
Long non-coding RNAs (lncRNAs) contribute to cardiac (patho)physiology. Aging is the major risk factor for cardiovascular disease with cardiomyocyte apoptosis as one underlying cause. Here, we report the identification of the aging-regulated lncRNA Sarrah (ENSMUST00000140003) that is anti-apoptotic in cardiomyocytes. Importantly, loss of SARRAH (OXCT1-AS1) in human engineered heart tissue results in impaired contractile force development. SARRAH directly binds to the promoters of genes downregul...    »
 
Journal title abbreviation:
Nat Commun 
Year:
2020 
Journal volume:
11 
Journal issue:
Print-ISSN:
2041-1723 
TUM Institution:
Institut für Pharmakologie und Toxikologie