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Document type:
Journal Article 
Author(s):
Coassin, Stefan; Hermann-Kleiter, Natascha; Haun, Margot; Wahl, Simone; Wilson, Rory; Paulweber, Bernhard; Kunze, Sonja; Meitinger, Thomas; Strauch, Konstantin; Peters, Annette; Waldenberger, Melanie; Kronenberg, Florian; Lamina, Claudia 
Title:
A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter. 
Abstract:
Lipoprotein(a) [Lp(a)] is a major cardiovascular risk factor, which is largely genetically determined by one major gene locus, the LPA gene. Many aspects of the transcriptional regulation of LPA are poorly understood and the role of epigenetics has not been addressed yet. Therefore, we conducted an epigenome-wide analysis of DNA methylation on Lp(a) levels in two population-based studies (total n = 2208). We identified a CpG site in the LPA promoter which was significantly associated with Lp(a)...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2020 
Journal volume:
15 
Journal issue:
Print-ISSN:
1932-6203 
TUM Institution:
656; 658; Institut für Humangenetik