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Original title:
NMR structural studies of full-length Bcl-xL in nanodiscs 
Translated title:
NMR-struktrulle Studien von volllängen Bcl-xL in nanodiscs 
Year:
2020 
Document type:
Dissertation 
Institution:
Fakultät für Chemie 
Advisor:
Hagn, Franz (Prof. Dr.) 
Referee:
Hagn, Franz (Prof. Dr.); Reif, Bernd (Prof. Dr.) 
Language:
en 
Subject group:
CHE Chemie 
Keywords:
Bcl-xL, Nanodiscs, tail-anchored proteins, NMR 
Translated keywords:
Bcl-xL, Nanodiscs, tail-anchored proteins, NMR 
TUM classification:
CHE 887d 
Abstract:
The focus of this study is the development of new methods for the production of the full-length tail-anchored membrane proteins, specifically the B-cell lymphoma-extralarge (Bcl-xL), a member of the Bcl-2 family,as well as their structural investigation in phospholipid nanodiscs. The developed methods are applied to studying the membrane-bound and inserted Bcl-xL and to probe its membrane location and possible membrane insertion processes in a native-like environment. 
Translated abstract:
Der Fokus dieser Arbeit ist die Entwicklung neuer Methoden zur Produktion von tail-anchored Proteinen, insbesondere von Bcl-xL (B-cell lymphoma extra large), sowie deren strukturelle Untersuchung in Phospholipid Nanodiscs. Die entwickelten Methoden werden angewendet, um die membrangebundene und verankerte Form von Bcl-xL zu untersuchen und um deren Membranlokalisation beziehungsweise mögliche Membraninsertionsprozesse in einer möglichst nativen Umgebung zu erforschen. 
Oral examination:
10.02.2020 
File size:
9252596 bytes 
Pages:
208 
Last change:
09.06.2020