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Document type:
Journal Article 
Author(s):
Grismayer, B; Sato, S; Kopitz, C; Ries, C; Soelch, S; Schmitt, M; Baretton, G; Kruger, A; Luther, T; Kotzsch, M; Magdolen, V 
Title:
Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes. 
Abstract:
mRNA levels of the urokinase receptor splice variant uPAR-del4/5 are associated with prognosis in breast cancer. Its overexpression in cancer cells affects tumor biologically relevant processes. In the present study, individual breast cancer cell clones displaying low vs. high uPAR-del4/5 expression were analyzed demonstrating that uPAR-del4/5 leads to reduced cell adhesion and invasion in a dose-dependent manner. Additionally, matrix metalloproteinase-9 (MMP-9) was found to be strongly upregula...    »
 
Journal title abbreviation:
Biol Chem 
Year:
2012 
Journal volume:
393 
Journal issue:
12 
Pages contribution:
1449-55 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1431-6730 
TUM Institution:
Frauenklinik und Poliklinik; Institut für Experimentelle Onkologie und Therapieforschung