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Dokumenttyp:
journal article 
Autor(en):
Grismayer, B; Sato, S; Kopitz, C; Ries, C; Soelch, S; Schmitt, M; Baretton, G; Krüger, A; Luther, T; Kotzsch, M; Magdolen, V 
Titel:
Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes. 
Abstract:
mRNA levels of the urokinase receptor splice variant uPAR-del4/5 are associated with prognosis in breast cancer. Its overexpression in cancer cells affects tumor biologically relevant processes. In the present study, individual breast cancer cell clones displaying low vs. high uPAR-del4/5 expression were analyzed demonstrating that uPAR-del4/5 leads to reduced cell adhesion and invasion in a dose-dependent manner. Additionally, matrix metalloproteinase-9 (MMP-9) was found to be strongly upregula...    »
 
Zeitschriftentitel:
Biol Chem 
Jahr:
2012 
Band / Volume:
393 
Heft / Issue:
12 
Seitenangaben Beitrag:
1449-55 
Sprache:
eng 
Print-ISSN:
1431-6730 
TUM Einrichtung:
r experimentelle Onkologie und Therapieforschung; Frauenklinik und Poliklinik