Abstract:
The absolute configurations of chiral beta-mercaptoalkanones were determined. Enantiomers were obtained by lipase-catalyzed hydrolyses of the respective acetylthioalkanones and investigated by 1H-NMR analyses using different derivatizing agents. For a homologous series of 2-mercapto-4-alkanones (C6-C10), the absolute configurations of the enantiomers were assigned, and the impact of the stereochemistry on the sensory properties was investigated via GC/O.