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Document type:
journal article 
Author(s):
Lehmann, J; Vomacka, J; Esser, K; Nodwell, M; Kolbe, K; Ramer, P; Protzer, U; Reiling, N; Sieber, SA 
Title:
Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases 
Abstract:
Lalistat inhibits growth of Mycobacterium tuberculosis in bacterial culture as well as in infected macrophages. Target identification by quantitative proteomics revealed a cluster of 20 hydrolytic proteins including members of the lipase family. Lipases are essential for M. tuberculosis fatty acid production and energy storage thus representing promising antibiotic targets. 
Journal title abbreviation:
MedChemComm 
Year:
2016 
Journal volume:
Journal issue:
Pages contribution:
1797-1801 
Language:
eng 
Print-ISSN:
2040-2503 
TUM Institution:
Institut für Virologie