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Dokumenttyp:
journal article 
Autor(en):
Lehmann, J; Vomacka, J; Esser, K; Nodwell, M; Kolbe, K; Ramer, P; Protzer, U; Reiling, N; Sieber, SA 
Titel:
Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases 
Abstract:
Lalistat inhibits growth of Mycobacterium tuberculosis in bacterial culture as well as in infected macrophages. Target identification by quantitative proteomics revealed a cluster of 20 hydrolytic proteins including members of the lipase family. Lipases are essential for M. tuberculosis fatty acid production and energy storage thus representing promising antibiotic targets. 
Zeitschriftentitel:
MedChemComm 
Jahr:
2016 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
1797-1801 
Sprache:
eng 
Print-ISSN:
2040-2503 
TUM Einrichtung:
Institut für Virologie