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Document type:
journal article 
Author(s):
Kim, Seonil; Pick, Joseph E; Abera, Sinedu; Khatri, Latika; Ferreira, Danielle D P; Sathler, Matheus F; Morison, Sage L; Hofmann, Franz; Ziff, Edward B 
Title:
Brain region-specific effects of cGMP-dependent kinase II knockout on AMPA receptor trafficking and animal behavior. 
Abstract:
Phosphorylation of GluA1, a subunit of AMPA receptors (AMPARs), is critical for AMPAR synaptic trafficking and control of synaptic transmission. cGMP-dependent protein kinase II (cGKII) mediates this phosphorylation, and cGKII knockout (KO) affects GluA1 phosphorylation and alters animal behavior. Notably, GluA1 phosphorylation in the KO hippocampus is increased as a functional compensation for gene deletion, while such compensation is absent in the prefrontal cortex. Thus, there are brain regio...    »
 
Journal title abbreviation:
Learn Mem 
Year:
2016 
Journal volume:
23 
Journal issue:
Pages contribution:
435-41 
Language:
eng 
Print-ISSN:
1072-0502 
TUM Institution:
Institut für Pharmakologie und Toxikologie