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Dokumenttyp:
journal article 
Autor(en):
Kim, Seonil; Pick, Joseph E; Abera, Sinedu; Khatri, Latika; Ferreira, Danielle D P; Sathler, Matheus F; Morison, Sage L; Hofmann, Franz; Ziff, Edward B 
Titel:
Brain region-specific effects of cGMP-dependent kinase II knockout on AMPA receptor trafficking and animal behavior. 
Abstract:
Phosphorylation of GluA1, a subunit of AMPA receptors (AMPARs), is critical for AMPAR synaptic trafficking and control of synaptic transmission. cGMP-dependent protein kinase II (cGKII) mediates this phosphorylation, and cGKII knockout (KO) affects GluA1 phosphorylation and alters animal behavior. Notably, GluA1 phosphorylation in the KO hippocampus is increased as a functional compensation for gene deletion, while such compensation is absent in the prefrontal cortex. Thus, there are brain regio...    »
 
Zeitschriftentitel:
Learn Mem 
Jahr:
2016 
Band / Volume:
23 
Heft / Issue:
Seitenangaben Beitrag:
435-41 
Sprache:
eng 
Print-ISSN:
1072-0502 
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie