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Document type:
journal article 
Author(s):
Nowak, Christoph; Salihovic, Samira; Ganna, Andrea; Brandmaier, Stefan; Tukiainen, Taru; Broeckling, Corey D; Magnusson, Patrik K; Prenni, Jessica E; Wang-Sattler, Rui; Peters, Annette; Strauch, Konstantin; Meitinger, Thomas; Giedraitis, Vilmantas; Ärnlöv, Johan; Berne, Christian; Gieger, Christian; Ripatti, Samuli; Lind, Lars; Pedersen, Nancy L; Sundström, Johan; Ingelsson, Erik; Fall, Tove 
Title:
Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study. 
Abstract:
Insulin resistance (IR) and impaired insulin secretion contribute to type 2 diabetes and cardiovascular disease. Both are associated with changes in the circulating metabolome, but causal directions have been difficult to disentangle. We combined untargeted plasma metabolomics by liquid chromatography/mass spectrometry in three non-diabetic cohorts with Mendelian Randomization (MR) analysis to obtain new insights into early metabolic alterations in IR and impaired insulin secretion. In up to 910...    »
 
Journal title abbreviation:
PLoS Genet 
Year:
2016 
Journal volume:
12 
Journal issue:
10 
Pages contribution:
e1006379 
Language:
eng 
Print-ISSN:
1553-7390 
TUM Institution:
Institut für Humangenetik