Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Steinbach, Karin; Vincenti, Ilena; Kreutzfeldt, Mario; Page, Nicolas; Muschaweckh, Andreas; Wagner, Ingrid; Drexler, Ingo; Pinschewer, Daniel; Korn, Thomas; Merkler, Doron 
Titel:
Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection. 
Abstract:
Tissue-resident memory T cells (TRM) persist at sites of prior infection and have been shown to enhance pathogen clearance by recruiting circulating immune cells and providing bystander activation. Here, we characterize the functioning of brain-resident memory T cells (bTRM) in an animal model of viral infection. bTRM were subject to spontaneous homeostatic proliferation and were largely refractory to systemic immune cell depletion. After viral reinfection in mice, bTRM rapidly acquired cytotoxi...    »
 
Zeitschriftentitel:
J Exp Med 
Jahr:
2016 
Band / Volume:
213 
Heft / Issue:
Seitenangaben Beitrag:
1571-87 
Sprache:
eng 
Print-ISSN:
0022-1007 
TUM Einrichtung:
Lehrstuhl für Molekulare Neuroimmunologie