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Dokumenttyp:
journal article 
Autor(en):
Reinhardt, Annika; Yevsa, Tetyana; Worbs, Tim; Lienenklaus, Stefan; Sandrock, Inga; Oberdörfer, Linda; Korn, Thomas; Weiss, Siegfried; Förster, Reinhold; Prinz, Immo 
Titel:
Interleukin-23-Dependent ?/? T Cells Produce Interleukin-17 and Accumulate in the Enthesis, Aortic Valve, and Ciliary Body in Mice. 
Abstract:
The spondyloarthritides (SpA) are a group of rheumatic diseases characterized by ossification and inflammation of entheseal tissue, the region where tendon attaches to bone. Interleukin-23 (IL-23) is involved in the pathogenesis of SpA by acting on IL-23 receptor (IL-23R) expressed on enthesis-resident lymphocytes. Upon IL-23 binding, CD3+CD4-CD8- tissue-resident lymphocytes secrete IL-17A and IL-22, leading to inflammation, bone loss, and ossification. Knowledge about enthesis-resident lymphocy...    »
 
Zeitschriftentitel:
Arthritis Rheumatol 
Jahr:
2016 
Band / Volume:
68 
Heft / Issue:
10 
Seitenangaben Beitrag:
2476-86 
Sprache:
eng 
Print-ISSN:
2326-5205 
TUM Einrichtung:
Lehrstuhl für Molekulare Neuroimmunologie