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Dokumenttyp:
journal article 
Autor(en):
Wülfing, C; Machiels, JP; Richel, DJ; Grimm, MO; Treiber, U; De Groot, MR; Beuzeboc, P; Parikh, R; Pétavy, F; El-Hariry, IA 
Titel:
A single-arm, multicenter, open-label phase 2 study of lapatinib as the second-line treatment of patients with locally advanced or metastatic transitional cell carcinoma. 
Abstract:
BACKGROUND: The treatment of recurrent transitional cell carcinoma (TCC) remains an unmet clinical need. This study assessed lapatinib, a dual tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR) and HER-2, as second-line therapy in patients with locally advanced or metastatic TCC. METHODS: This was a single-arm, multicenter, open-label, prospective phase 2 study. Patients with TCC whose disease progressed on prior platinum-based chemotherapy received lapatinib until disease prog...    »
 
Zeitschriftentitel:
Cancer 
Jahr:
2009 
Band / Volume:
115 
Heft / Issue:
13 
Seitenangaben Beitrag:
2881-90 
Sprache:
eng 
Print-ISSN:
0008-543X 
TUM Einrichtung:
Urologische Klinik und Poliklinik