User: Guest  Login
Document type:
journal article 
Author(s):
Kleppisch, T 
Title:
Phosphodiesterases in the central nervous system. 
Abstract:
Phosphodiesterases (PDEs) represent important cornerstones of cGMP signaling in various tissues. Since the discovery of PDE activity in 1962, it has become clear that the functional characteristics of PDEs and their role in cyclic nucleotide signaling are fairly complex. On the one hand, members of the PDE family responsible for the hydrolysis of cGMP affect cellular responses by shaping cGMP signals derived from the activation of soluble cytosolic and/or membrane bound particulate guanylyl cycl...    »
 
Journal title abbreviation:
Handb Exp Pharmacol 
Year:
2009 
Journal issue:
191 
Pages contribution:
71-92 
Language:
eng 
Print-ISSN:
0171-2004 
TUM Institution:
Institut für Pharmakologie und Toxikologie