User: Guest  Login
Document type:
journal article 
Author(s):
Scheikl, T; Reis, B; Pfeffer, K; Holzmann, B; Beer, S 
Title:
Reduced notch activity is associated with an impaired marginal zone B cell development and function in Sly1 mutant mice. 
Abstract:
MZ B cells represent a distinct lineage of naive B lymphocytes, apart from FO B cells and peritoneal B1 cells, and mediate humoral immune responses against blood-borne type 2 T-independent antigens. Regulation of MZ B cell development involves the Notch receptor signaling, the intensity of B cell receptor signals, and cell compartmentalization by adhesion and chemokine receptors. Our previous work showed that gene-targeted mice expressing a truncated form of the putative signaling adapter protei...    »
 
Journal title abbreviation:
Mol Immunol 
Year:
2009 
Journal volume:
46 
Journal issue:
Pages contribution:
969-77 
Language:
eng 
Print-ISSN:
0161-5890 
TUM Institution:
Chirurgiesche Klinik und Poliklinik