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Dokumenttyp:
journal article 
Autor(en):
Nuhn, P; Künzli, BM; Hennig, R; Mitkus, T; Ramanauskas, T; Nobiling, R; Meuer, SC; Friess, H; Berberat, PO 
Titel:
Heme oxygenase-1 and its metabolites affect pancreatic tumor growth in vivo. 
Abstract:
BACKGROUND: Pancreatic cancer (PaCa) is a fatal human cancer due to its exceptional resistance to all current anticancer therapies. The cytoprotective enzyme heme oxygenase-1 (HO-1) is significantly overexpressed in PaCa and seems to play an important role in cancer resistance to anticancer treatment. The inhibition of HO-1 sensitized PaCa cells to chemo- and radiotherapy in vitro. Therefore, we investigated the effects of HO-1 and its metabolites biliverdin, carbon monoxide and iron on PaCa cel...    »
 
Zeitschriftentitel:
Mol Cancer 
Jahr:
2009 
Band / Volume:
Seitenangaben Beitrag:
37 
Sprache:
eng 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik