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Dokumenttyp:
journal article 
Autor(en):
Büchler, P; Reber, HA; Tomlinson, JS; Hankinson, O; Kallifatidis, G; Friess, H; Herr, I; Hines, OJ 
Titel:
Transcriptional regulation of urokinase-type plasminogen activator receptor by hypoxia-inducible factor 1 is crucial for invasion of pancreatic and liver cancer. 
Abstract:
Angioinvasion is critical for metastasis with urokinase-type plasminogen activator receptor (uPAR) and tumor hypoxia-activated hypoxia-inducible factor 1 (HIF-1) as key players. Transcriptional control of uPAR expression by HIF has never been reported. The aim of the present study, therefore, was to test whether tumor hypoxia-induced HIF expression may be linked to transcriptional activation of uPAR and dependent angioinvasion. We used human pancreatic cancer cells and a model of parental and de...    »
 
Zeitschriftentitel:
Neoplasia 
Jahr:
2009 
Band / Volume:
11 
Heft / Issue:
Seitenangaben Beitrag:
196-206 
Sprache:
eng 
Print-ISSN:
1522-8002 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik