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Document type:
journal article 
Author(s):
Klohs, J; Steinbrink, J; Bourayou, R; Mueller, S; Cordell, R; Licha, K; Schirner, M; Dirnagl, U; Lindauer, U; Wunder, A 
Title:
Near-infrared fluorescence imaging with fluorescently labeled albumin: a novel method for non-invasive optical imaging of blood-brain barrier impairment after focal cerebral ischemia in mice. 
Abstract:
Impairment of the blood-brain barrier (BBB) after cerebral ischemia leads to extravasation of plasma constituents into the brain parenchyma. We describe a novel method using non-invasive near-infrared fluorescence (NIRF) imaging and bovine serum albumin labeled with a NIRF dye (NIRF-BSA) to detect BBB impairment after middle cerebral artery occlusion (MCAO) in mice. We first explored the time course of BBB impairment after transient MCAO using Evans blue (EB), which binds to plasma albumin in vi...    »
 
Journal title abbreviation:
J Neurosci Methods 
Year:
2009 
Journal volume:
180 
Journal issue:
Pages contribution:
126-32 
Language:
eng 
Print-ISSN:
0165-0270 
TUM Institution:
Neurochirurgische Klinik und Poliklinik