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Dokumenttyp:
journal article 
Autor(en):
Rusai, K; Wagner, B; Roos, M; Schmaderer, C; Strobl, M; Boini, KM; Grenz, A; Kuhl, D; Heemann, U; Lang, F; Lutz, J 
Titel:
The serum and glucocorticoid-regulated kinase 1 in hypoxic renal injury. 
Abstract:
The serum- and glucocorticoid-inducible kinase 1 (SGK1) is a serine threonine protein kinase activated through the phosphatidylinositol 3-kinase (PI3-kinase) pathway and counteracting apoptosis. Protein expression and activation of SGK1 are increased in various models of cell stress. The present study explored the role of SGK1 in renal hypoxia/ischemia induced apoptosis. HEK 293 cells were exposed in vitro to hypoxia/reoxygenation (H/R), which increased SGK1 transcript levels, SGK1 protein abund...    »
 
Zeitschriftentitel:
Cell Physiol Biochem 
Jahr:
2009 
Band / Volume:
24 
Heft / Issue:
5-6 
Seitenangaben Beitrag:
577-84 
Sprache:
eng 
Print-ISSN:
1015-8987 
TUM Einrichtung:
r Nephrologie