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Dokumenttyp:
journal article 
Autor(en):
Altomonte, J; Wu, L; Meseck, M; Chen, L; Ebert, O; Garcia-Sastre, A; Fallon, J; Mandeli, J; Woo, SL 
Titel:
Enhanced oncolytic potency of vesicular stomatitis virus through vector-mediated inhibition of NK and NKT cells. 
Abstract:
Recombinant oncolytic viruses represent a promising alternative option for the treatment of malignant cancers. We have reported earlier the safety and efficacy of recombinant vesicular stomatitis virus (VSV) vectors in a rat model of hepatocellular carcinoma (HCC). However, the full potential of VSV therapy is limited by a sudden decline in intratumoral virus replication observed early after viral administration, a phenomenon that coincides with an accumulation of inflammatory cells within infec...    »
 
Zeitschriftentitel:
Cancer Gene Ther 
Jahr:
2009 
Band / Volume:
16 
Heft / Issue:
Seitenangaben Beitrag:
266-78 
Sprache:
eng 
Print-ISSN:
0929-1903 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik