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Dokumenttyp:
journal article 
Autor(en):
Yang, R; Chen, B; Hemminki, K; Wappenschmidt, B; Engel, C; Sutter, C; Ditsch, N; Weber, BH; Niederacher, D; Arnold, N; Meindl, A; Bartram, CR; Schmutzler, RK; Burwinkel, B 
Titel:
Polymorphisms in BRCA2 resulting in aberrant codon-usage and their analysis on familial breast cancer risk. 
Abstract:
Mutations in BRCA1 and BRCA2 are associated with increased breast cancer risk. While numerous non-synonymous SNPs in BRCA1/2 have been investigated for breast cancer risk, the impact of synonymous SNPs has not been studied so far. Recently, it has been reported that synonymous SNPs leading to an aberration from the preferred codon-usage can have functional effects and consequently be associated with disease. This motivated us to search for SNPs with the tendency to differential codon-usage in BR...    »
 
Zeitschriftentitel:
Breast Cancer Res Treat 
Jahr:
2009 
Band / Volume:
118 
Heft / Issue:
Seitenangaben Beitrag:
407-13 
Sprache:
eng 
Print-ISSN:
0167-6806 
TUM Einrichtung:
Frauenklinik und Poliklinik