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Dokumenttyp:
journal article 
Autor(en):
Lohmann, C; Muschaweckh, A; Kirschnek, S; Jennen, L; Wagner, H; Häcker, G 
Titel:
Induction of tumor cell apoptosis or necrosis by conditional expression of cell death proteins: analysis of cell death pathways and in vitro immune stimulatory potential. 
Abstract:
For the efficient stimulation of T cells by tumor Ag, tumor-derived material has to be presented by dendritic cells (DC). This very likely involves the uptake of dead tumor cells by DC. Cell death in tumors often occurs through apoptosis, but necrotic cell death may also be prevalent. This distinction is relevant because numerous studies have proposed that apoptotic cells have immunosuppressive effects while necrosis may be stimulatory. However, a system has been lacking that would allow the ind...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2009 
Band / Volume:
182 
Heft / Issue:
Seitenangaben Beitrag:
4538-46 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene