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Document type:
journal article 
Author(s):
Navarini, AA; Lang, KS; Verschoor, A; Recher, M; Zinkernagel, AS; Nizet, V; Odermatt, B; Hengartner, H; Zinkernagel, RM 
Title:
Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections. 
Abstract:
Neutrophils are the most abundant leukocytes in circulation and provide a primary innate immune defense function against bacterial pathogens before development of a specific immune response. These specialized phagocytes are short lived (12-24 hours) and continuously replenished from bone marrow. We found that if the host is overwhelmed by a high inoculum of Listeria monocytogenes, neutrophils are depleted despite high granulocyte-colony stimulating factor induction. In contrast to a low-dose inn...    »
 
Journal title abbreviation:
Proc Natl Acad Sci U S A 
Year:
2009 
Journal volume:
106 
Journal issue:
17 
Pages contribution:
7107-12 
Language:
eng 
Print-ISSN:
0027-8424 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene