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Document type:
journal article 
Author(s):
Brenk, M; Scheler, M; Koch, S; Neumann, J; Takikawa, O; Häcker, G; Bieber, T; von Bubnoff, D 
Title:
Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4+CD25+ Foxp3+ T regulatory cells. 
Abstract:
Tryptophan catabolism through IDO activity can cause nonresponsiveness and tolerance acting on T cells. Given the crucial importance of dendritic cells (DCs) in the initiation of a T cell response, surprisingly little is known about the impact of IDO activity and tryptophan deprivation on DCs themselves. In the present study, we show that human DCs differentiated under low-tryptophan conditions acquire strong tolerogenic capacity. This effect is associated with a markedly decreased Ag uptake as...    »
 
Journal title abbreviation:
J Immunol 
Year:
2009 
Journal volume:
183 
Journal issue:
Pages contribution:
145-54 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene