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Dokumenttyp:
journal article 
Autor(en):
Haas, T; Schmitz, F; Heit, A; Wagner, H 
Titel:
Sequence independent interferon-alpha induction by multimerized phosphodiester DNA depends on spatial regulation of Toll-like receptor-9 activation in plasmacytoid dendritic cells. 
Abstract:
Single-stranded versus multimeric phosphorothioate-modified CpG oligodeoxynucleotides (ODNs) undergo differential endosomal trafficking upon uptake into plasmacytoid dendritic cells (pDCs), correlating with Toll-like receptor-9-dependent pDC maturation/activation (single-stranded B-type CpG ODN) or interferon-alpha (IFN-alpha) induction (multimeric A-type CpG ODN), respectively. As was recently shown, IFN-alpha production, other than by CpG ODNs, can also be induced in a sequence-independent man...    »
 
Zeitschriftentitel:
Immunology 
Jahr:
2009 
Band / Volume:
126 
Heft / Issue:
Seitenangaben Beitrag:
290-8 
Sprache:
eng 
Print-ISSN:
0019-2805 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik; r Medizinische Mikrobiologie, Immunologie und Hygiene